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As laboratory demands change and technological progress continues, the functions of a LIMS will likely also change.

Key features includebut are not limited toworkflow and data tracking support, flexible architecture, and data exchange interfaces, which fully support its use in regulated environments.

The definition of a LIMS is somewhat controversial: LIMSs are dynamic because the laboratorys requirements are rapidly evolving and different labs often have different needs.

Therefore, a working definition of a LIMS ultimately depends on the interpretation by the individuals or groups involved.

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Historically the LIMS, LIS, and process development execution system (PDES) have all performed similar functions.

The term LIMS has tended to refer to informatics systems targeted for environmental, research, or commercial analysis such as pharmaceutical or petrochemical work.

LIS has tended to refer to laboratory informatics systems in the forensics and clinical markets, which often required special case management tools.

PDES has generally applied to a wider scope, including, for example, virtual manufacturing techniques, while not necessarily integrating with laboratory equipment.

In recent times LIMS functionality has spread even farther beyond its original purpose of sample management.

Assay data management, data mining, data analysis, and electronic laboratory notebook (ELN) integration have been added to many LIMS, enabling the realization of translational medicine completely within a single software solution.

Additionally, the distinction between LIMS and LIS has blurred, as many LIMS now also fully support comprehensive case-centric clinical data.

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Technology 2.1 Operations 2.2 Client-side options History edit Up until the late 1970s, the management of laboratory samples and the associated analysis and reporting were time-consuming manual processes often riddled with transcription errors.

This gave some organizations impetus to streamline the collection of data and how it was reported.

Custom in-house solutions were developed by a few individual laboratories, while some enterprising entities at the same time sought to develop a more commercial reporting solution in the form of special instrument-based systems.

In 1982 the first generation of LIMS was introduced in the form of a single centralized minicomputer, which offered laboratories the first opportunity to utilize automated reporting tools.

As the interest in these early LIMS grew, industry leaders like Gerst Gibbon of the Federal Energy Technology Center in Pittsburgh began planting the seeds through LIMS-related conferences.

By 1988 the second-generation commercial offerings were tapping into relational databases to expand LIMS into more application-specific territory, and International LIMS Conferences were in full swing.

As personal computers became more powerful and prominent, a third generation of LIMS emerged in the early 1990s.

These new LIMS took advantage of clientserver architecture, allowing laboratories to implement better data processing and exchanges.

By 1995 the clientserver tools had developed to the point of allowing processing of data anywhere on the network.

Web-enabled LIMS were introduced the following year, enabling researchers to extend operations outside the confines of the laboratory.

From 1996 to 2002 additional functionality was included in LIMS, from wireless networking capabilities and georeferencing of samples, to the adoption of XML standards and the development of Internet purchasing.

As of 2012, some LIMS have added additional characteristics that continue to shape how a LIMS is defined.

Additions include clinical functionality, electronic laboratory notebook (ELN) functionality, as well a rise in the software as a service (SaaS) distribution model.

Technology edit Operations edit The LIMS is an evolving concept, with new features and functionality being added often.

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